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Connective Tissue Ensheathment of Nerves
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Slide 13: Nerve bundles - x.s., Mallory's trichrome stain (collagen - blue; fibroblasts - red; myelin - yellow sometimes; axons - red). Note the epineurium, perineurium, and endoneurium. Endoneurium is a delicate layer of connective tissue which surrounds each nerve fiber (it is visible here because the collagen is stained blue). Perineurium surrounds each nerve bundle(fascicle), and epineurium surrounds a collection of nerve bundles. Locate axons (axis cylinders) and myelin ghosts. Besides fibroblasts and other connective tissue cells, to what cell types would nuclei within this nerve bundle belong? ANS: endothelial cells and Schwann cells. The Schwann cell is the ensheathing cell of the PNS.