Correct.

The correct answer is enhance.
For each one point drop of the pKa of a basic drug, its ratio of protonated/non-protonated form will drop by 10 fold (i.e. : more exists in the non-protonated form). Hence, more will exist in the uncharged form, i.e.: in the form that can be taken up the most efficiently.

Incorrect.

The correct answer is enhance.
For each one point drop of the pKa of a basic drug, its ratio of protonated/non-protonated form will drop by 10 fold (i.e. : more exists in the non-protonated form). Hence, more will exist in the uncharged form, i.e.: in the form that can be taken up the most efficiently.

 

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