Omeprazole Action on the Parietal Cell
Omeprazole is a weak base. In the acidic milieu of the stomach,
it becomes protonated (i.e. charged, and hence trapped outside
the cell, where it can interact with the cell's ATPase H-PUMP).
Protonation also converts omeprazole into a reactive compound that
reacts covalently with sulfhydryl groups on the ATPase H-pump,
thereby irreversibly inhibiting hydrogen ion secretion into the
lumen.
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