In the Mechanisms of Disease modules the pathology, pathophysiology, and pharmacology of disease are approached in an organ-system-based, multidisciplinary manner centered around problem-solving. This module, in many ways, represents the transition from basic science to the clinical practice of medicine. Our overall goal is to convey an understanding of how normal human biology goes awry in disease, and how biological insight can lead to pharmacological and/or surgical intervention. The course is structured according to individual organ systems, and each organ system block is co-taught by multiple departments. This instruction is fully coordinated with acquisition of clinical skills through the parallel Skills and Science of Doctoring module. The emphasis is on relating pathogenic mechanisms to the clinical manifestations of disease; introductory lectures are followed by precepted, small group discussions, seminars, and student-patient sessions.