DNA Replication Quiz

REVIEW OF THE BASICS OF DNA REPLICATION AND
DNA REPAIR — QUIZ

Question 1 of 8
1. Tautomerization describes:
- A transient rearrangement of bonding in DNA nucleotide bases.
- Formation of cyclobutane pyrimidine dimers.
- A conversion of B-form to A-form DNA.
- A heat-induced unwinding of a DNA helix.
- A transient rearrangement of bonding in DNA nucleotide bases.
- Uhh no. The correct answer is:
  A transient rearrangement of bonding in DNA nucleotide bases.
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Question 2 of 8
2. Okazaki fragments are predominantly synthesized by:
- DNA polymerase delta and DNA polymerase epsilon.
- DNA polymerase alpha and DNA polymerase epsilon.
- DNA polymerase alpha and DNA polymerase delta.
- DNA polymerase alpha alone.
- DNA polymerase alpha and DNA polymerase delta.
- Uhh no. The correct answer is:
  DNA polymerase alpha and DNA polymerase delta.
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Question 3 of 8
3. Single-strand DNA-binding proteins:
- Primarily function on the leading strand DNA template during DNA replication.
- Prevent the formation of secondary structures in single-stranded DNA.
- Are inhibitory to nucleotide incorporation by DNA polymerases.
- Catalyze ATP-dependent unwinding of duplex DNA.
- Prevent the formation of secondary structures in single-stranded DNA.
- Uhh no. The correct answer is:
  Prevent the formation of secondary structures in single-stranded DNA.
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Question 4 of 8
4. DNA polymerase proofreading:
- Occurs after the passage of the replication fork, using the mismatch repair machinery.
- Involves the excision of 5 to 10 nucleotides on the nascent strand.
- Is catalyzed by an exonuclease associated with DNA polymerase theta.
- Is activated after a 3’ mismatch causes stalling of the replicative DNA polymerase.
- Is activated after a 3’ mismatch causes stalling of the replicative DNA polymerase.
- Uhh no. The correct answer is:
  Is activated after a 3’ mismatch causes stalling of the replicative DNA polymerase.
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Question 5 of 8
5. Type II topoisomerases:
- Can cause mitotic catastrophe when inhibited.
- Are needed to remove torsional stress caused by replication fork movement.
- Support chromosomal decondensation after mitosis.
- Involve transient nicking of only one of the two DNA strands.
- Can cause mitotic catastrophe when inhibited.
- Uhh no. The correct answer is:
  Can cause mitotic catastrophe when inhibited.
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Question 6 of 8
6. The p53 gene product is induced in the presence:
- DNA damage.
- Hypoxia.
- Hyperproliferative signals emanating from oncogenes.
- All of the above.
- All of the above.
- Uhh no. The correct answer is:
  All of the above.
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Question 7 of 8
7. Spontaneous deamination of 5-methyl cytosine in duplex DNA:
- Gives the nucleoside base uracil.
- Is a hallmark of Xeroderma Pigmentosum (XP).
- Can result in loss of CpG sites over many cell generations.
- Leads to over-representation of CpG sites in the genome.
- Can result in loss of CpG sites over many cell generations.
- Uhh no. The correct answer is:
  Can result in loss of CpG sites over many cell generations.
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Question 8 of 8
8. In duplex DNA, mutagenic alterations of nucleotide base structure:
- Can occur because of spontaneous reactions resulting from normal base chemistry.
- Are only repaired by Base Excision Repair
- Are found with higher frequency in Lynch Syndrome
- Are clinically treated with cisplatin
- Can occur because of spontaneous reactions resulting from normal base chemistry
- Uhh no. The correct answer is:
  Can occur because of spontaneous reactions resulting from normal base chemistry
Get Your ScoreCheck Your Answer!

1. Tautomerization describes:

2. Okazaki fragments are predominantly synthesized by:

3. Single-strand DNA-binding proteins:

4. DNA polymerase proofreading:

5. Type II topoisomerases:

6. The p53 gene product is induced in the presence:

7. Spontaneous deamination of 5-methyl cytosine in duplex DNA:

8. In duplex DNA, mutagenic alterations of nucleotide base structure:

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