CORE FOUNDATIONS FOR MEDICINE TUTORIAL ON EICOSANOIDS

Eicosanoids are synthesized primarily from arachidonic acid.

  • Glucocorticoids reduce inflammation in part by inhibiting eicosanoid production by macrophages.
    • Phosholipase A2α is inhibited by the protein Annexin-1
    • Annexin-1 synthesis by macrophages is stimulated by glucocorticoids such as cortisol.
    • Annexin-1 also works by other mechansims, some of which are described later in the tutorial.
    • Glucocorticoids also work by other mechanisms, some of which are described later in the tutorial.

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