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Glucocorticoids reduce inflammation in part by inhibiting eicosanoid production by macrophages.
- Phosholipase A2α is inhibited by the protein Annexin-1
- Annexin-1 synthesis by macrophages is stimulated by glucocorticoids such as cortisol.
- Annexin-1 also works by other mechansims, some of which are described later in the tutorial.
- Glucocorticoids also work by other mechanisms, some of which are described later in the tutorial.
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