CORE FOUNDATIONS FOR MEDICINE TUTORIAL ON EICOSANOIDS

Leukotriene Receptors

Leukotrienes signal via Gi and Gq G-protein coupled receptors. Hence they lead to smooth muscle contraction.
There are two classes of LT receptors
  • LTB activation promotes inflammation.
    • LTB receptors are present on immune cells.
  • CysLT receptors promote inflammation and bronchioconstriction. They are present on:
    • Immune cells (e.g. mast cells)
    • Smooth muscle cells
In the airways, smooth muscle contraction leads to bronchioconstriction.

The allergy and asthma drug montelukast (Singulair) is a cysLT receptor antagonist

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