1. During an inflamatory response, epithelial cells convert arachidonic acid to 15-hydroxyarachidonic acid. (The arachidonic acid is prodced via phospholipase A2).
Lipoxins Lipoxin synthesis requires an interaction between leukocytes and other cells.
Example: Interaction between an epithelial cell and a leukocyte
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1. During an inflamatory response, epithelial cells convert arachidonic acid to 15-hydroxyarachidonic acid. (The arachidonic acid is prodced via phospholipase A2). |
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| 2. 15-hydroxyarachidonic acid is transferred to interacting leukocytes, which convert it to lipoxins. (During an inflammatory response, 5-lipoxygenase is associated with FLAP and is active). | |
| 3. Lipoxins are produced and secreted into the blood |