FM1 TUTORIAL ON EICOSANOIDS

Eicosanoids are synthesized primarily from arachidonic acid.

  • Arachidonic acid is a component of phospholipids in the E.R. and nuclear membranes.
    • Arachidonic acid is released from the membranes primarily by cytosolic phospholipase A2α (cPLA2α).
    • A small amount of arachidonic acid can be released by phospholipase C (the lipase that is activated by Gq-signaling)

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