CORE FOUNDATIONS FOR MEDICINE TUTORIAL ON EICOSANOIDS

Drugs and Blood Clotting

Selective COX-2 inhibitors such as Celebrex work by inhibiting COX-2 with very little effect on COX-1

 

COX-2 inhibitors are able to reduce pain, fever and inflammation without some of the side effects of aspirin.
  • COX-1 inhibition by high dose aspirin can cause stomach distress. This will be discussed in the eicosanoids lecture.
Selective COX-2 inhibitors do have the adverse side effect of promoting clot formation.
  • The adverse side effect of promoting clot formation can be understood in terms of alterations to the PGI/TXA balance.

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