- factors that stimulate clotting activate
G-protein coupled receptors on platelets
- phospholipase A2 is activated
- PGH synthesized by COX-1 is converted to TXA
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- TXA acts via autocrine signaling or diffuses a short distance to neighboring platelets
- TXA binds to the thromboxane receptor (TP), a Gq-linked G-protein coupled receptor
- Ca2+ concentration increases
- Ca2+ promotes platelet aggregation
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