FM1 TUTORIAL ON EICOSANOIDS

Thromboxane Stimulates clotting

I. Platelets produce Thromboxane (TXA)       II. TXA stimulates platelet aggregation and clotting
  • factors that stimulate clotting activate
    G-protein coupled receptors on platelets
  • phospholipase A2 is activated
  • PGH synthesized by COX-1 is converted to TXA
     
     
  • TXA acts via autocrine signaling or diffuses a short distance to neighboring platelets
  • TXA binds to the thromboxane receptor (TP), a Gq-linked G-protein coupled receptor
  • Ca2+ concentration increases
  • Ca2+ promotes platelet aggregation


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