- Factors that stimulate clotting activate receptors on platelets
- Phospholipase A2 is activated
- PGH produced by COX-1 is converted to TXA
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- TXA diffuses a short distance to neighboring smooth muscle cells
- TXA binds to the thromboxane receptor (TP), a Gq-linked G-protein coupled receptor
- Ca2+ concentration increases
- Ca2+ causes phosphorylation of myosin light chain
- Vasoconstriction results
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