CORE FOUNDATIONS FOR MEDICINE TUTORIAL ON EICOSANOIDS

Normal blood flow inhibits clotting

I. Prostacyclin (PGI) is produced by endothelial cells            II. Prostacyclin reduces platelet aggregation
  • shear forces of blood flow stimulates a mechanoreceptor
  • phospholipase A2 is activated
  • PGH synthesized by COX-1 and COX-2 is converted to PGI
     
     
  • PGI diffuses a short distance to neighboring platelets
  • PGI binds to a Gs-linked G-protein coupled receptor
  • cAMP concentration increases
  • cAMP reduces platelet aggregation

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