- shear forces of blood flow stimulates a mechanoreceptor
- phospholipase A2 is activated
- PGH synthesized by COX-1 and COX-2 is converted to PGI
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- PGI diffuses a short distance to neighboring platelets
- PGI binds to a Gs-linked G-protein coupled receptor
- cAMP concentration increases
- cAMP reduces platelet aggregation
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