- Shear forces of blood flow stimulate a mechanoreceptor
- Phospholipase A2 is activated
- PGH synthesized by COX-1 and COX-2 is converted to PGI
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- PGI diffuses a short distance to neighboring smooth muscle cells
- PGI binds to a Gs-linked G-protein coupled receptor
- cAMP concentration increases
- cAMP causes smooth muscle relaxation
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